Seth Meyers and Paul Rudd day drinking goes hilariously off the rails (2025)

On Late Night With Seth Meyers, the eponymous talk show host took Death of a Unicorn star Paul Rudd day drinking, and the results are as delightfully chaotic as you would hope.

The popular Seth Goes Day Drinking series has previously welcomed guests like Julia Louis-Dreyfuss, Kristen Stewart, Dua Lipa, Will Forte, Lizzo, Rihanna, Lorde, Retta, and Kelly Clarkson. This time, the bar-set segment kicks off with the longtime friends chugging horrific-sounding cocktails which are inspired by some standouts in Rudd's filmography. The Ant-Man cocktail is fittingly made of alcohol poured from tiny bottles, while the Knocked Up is a blended monstrosity of foods that pregnant people crave. (And yes, Meyers insists he must make eye contact with Rudd while blending.)

But the worst of the drinks has to be the Romeo + Juliet, in which Rudd played the unalluring suitor Count Paris. "Everything in this will kill you," Meyers tells Rudd. And he's not wrong! The catastrophic combination of Four Loko, Five Hour Energy, and Hot Sauce sends the pair into a spiral so bad that they apparently had to pause filming and wait three days to finish the shoot.

Luckily, Rudd comes back with a vengeance (albeit without his unicorn-themed cowboy height) for a series of games. Watch the whole video above to see Rudd and Meyers recreate scenes from Taken, shoot unicorn heads with Ghostbusters proton packs, and potentially break the record for biggest belch ever heard on the show.

Death of a Unicorn is now playing in theaters.